The research aim is to increase the morphofunctional status of newborn caves. Holstein cows of high productivity and their were chosen for research work. To conduct research from among pregnant cows after drying off, 2 groups of 15 heads each (control, experimental) were formed according to the principle of pairs of analogues. The animals of the experimental group were injected with Immunopharm intramuscularly three times with an interval of 7 days at a dose of 6.0 ml 10 days after drying off. Blood of cows from the studied groups was tested before and after administration of the drug to determine hematological and biochemical parameters. Сalves born by cows from studied groups were tested for morphofunctional status (viability) within the first hour after birth. Based on the conducted studies, it was found that the use of Immunopharm at a dose of 6.0 ml three times intramuscularly with an interval of 7 days during 10 days after the drying off period provides an increase of the amount of hemoglobin in the blood by 7.24 g/l, leukocytes - by 1.62×109/l total protein - by 0.83 g/ l, platelets - by 195.30×109/l, calcium - by 0.74 mmol/l, glucose - by 0.85 mmol/l, albumins - by 4.19%, α-globulins - by 3.33%. A decrease in the content of β-globulins - by 4.05%, ALaT and ASaT enzymes - by 14.93 and 14.47% compared with the blood indicators of animals from the control group, provides an increase in the morphofunctional status of calves born by cows according to the following indicators: the condition of skin, a reduction of the duration of the standing posture reflex by 3.85 minutes, the sucking reflex by 4.02 minutes, an increase of indicators, featuring maturation of skeletal system, hematological parameters and liveweight, which indicates the effectiveness of Immunopharm drug for the correction of metabolism of highly productive cows during the drying off period.