The purpose of the research is to increase the yield of winter wheat using growth stimulants, microbiological fertilizers, biofungicide in the conditions of the forest-steppe zone of the Middle Volga region. The soil of the experimental site is leached chernozem, medium loamy. The main factor affecting productivity, yield, gluten content, profitability level are macro- and micro-fertilizers, growth stimulants. The effect of Pekacid is less significant. The use of growth stimulants, microbiological fertilizers and biofungicide in winter wheat crops increased the photosynthetic activity of crops, yield and grain quality. The highest yield (5.14 t/ha) and an increase (750 kg/ha) were obtained using a tank mixture (Biodux + Organit P + Organit N + Orgamica S + Stimax). A slightly lower yield (5.03 t/ha) was obtained using a four-component tank mixture (Biodux + Organit P + Organit N + Orgamica S). In third place is the variant (Biodux + Organit P + Organit N + Pekacid), where 4.84 t/ha was collected from 1 ha. In variants of tank mixtures, with the use of Pekacid, the percentage of gluten increases compared to the control. The use of Pekacid preparation for foliar top dressing contributed to an increase in yield in all variants of the experiment compared with variants without the use of the preparation. The use of tank mixtures together with the Pekacid preparation in winter wheat crops is more effective compared to the use of preparations separately (variants 2 and 3) and contributes to an increase in net income and profitability.