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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Bulletin Samara State Agricultural Academy</journal-id><journal-title-group><journal-title xml:lang="en">Bulletin Samara State Agricultural Academy</journal-title><trans-title-group xml:lang="ru"><trans-title>Известия Самарской государственной сельскохозяйственной академии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1997-3225</issn><issn publication-format="electronic">2782-4225</issn><publisher><publisher-name xml:lang="en">Samara State Agrarian University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">683653</article-id><article-id pub-id-type="doi">10.55170/1997-3225-2025-10-1-79-85</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>VETERINARY MEDICINE AND ZOOTECHNICS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ВЕТЕРИНАРИЯ И ЗООТЕХНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Electrochemotherapy in the treatment of hemangiosarcoma in dogs (clinical case)</article-title><trans-title-group xml:lang="ru"><trans-title>Электрохимиотерапия при лечении гемангиосаркомы у собаки (клинический случай)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7980-8739</contrib-id><name-alternatives><name xml:lang="en"><surname>Grechko</surname><given-names>Viktor V.</given-names></name><name xml:lang="ru"><surname>Гречко</surname><given-names>Виктор Валентинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Veterinary Sciences, Associate Professor</p></bio><bio xml:lang="ru"><p>кандидат ветеринарных наук, доцент</p></bio><email>vg_1988@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0077-1860</contrib-id><name-alternatives><name xml:lang="en"><surname>Ovchinnikov</surname><given-names>Dmitry K.</given-names></name><name xml:lang="ru"><surname>Овчинников</surname><given-names>Дмитрий Константинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Veterinary Sciences, Associate Professor</p></bio><bio xml:lang="ru"><p>кандидат ветеринарных наук, доцент</p></bio><email>biolog-ivm@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Omsk State Agrarian University named after P.A. Stolypin</institution></aff><aff><institution xml:lang="ru">Омский государственный аграрный университет им. П.А. Столыпина</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-02-18" publication-format="electronic"><day>18</day><month>02</month><year>2025</year></pub-date><volume>10</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>79</fpage><lpage>85</lpage><history><date date-type="received" iso-8601-date="2025-06-09"><day>09</day><month>06</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-06-09"><day>09</day><month>06</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Grechko V.V., Ovchinnikov D.K.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Гречко В.В., Овчинников Д.К.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Grechko V.V., Ovchinnikov D.K.</copyright-holder><copyright-holder xml:lang="ru">Гречко В.В., Овчинников Д.К.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://bulletin.ssaa.ru/1997-3225/article/view/683653">https://bulletin.ssaa.ru/1997-3225/article/view/683653</self-uri><abstract xml:lang="en"><p>The article describes a clinical case of hemangiosarcoma treatment in a 7-year-old Labrador dog, local tumor control using intravenous bleomycin and subsequent tumor removal, as well as combined administration of calcium gluconate directly into the area of the tumor node. Hemangiosarcoma is a malignant tumor that is quite common in dogs in middle and older age. Labradors, German Shepherds, and Retrievers are the most susceptible to this disease. The causes of the identified cancer are not yet known, but it is safe to say that the main organs that are affected more often in an animal are the spleen, right atrium, skin and subcutaneous tissue, omentum, mesentery, liver. In 25% of dogs with a spleen tumor, the heart is affected. Tumors affecting only the epithelium of the skin are conditionally malignant. Less often – lungs, kidneys, mouth, muscles, bones, bladder, left ventricle, adrenal glands, brain, diaphragm, peritoneum, lymph nodes, tongue and fingers. Hemangiosarcoma is a highly aggressive tumor that metastasizes hematogenously or implantationally. Dogs without treatment live up to 3 months, with treatment – up to 6 months, 10% of patients survive a year. Along with the treatment of hemangiosarcoma, the diagnostic process is described, since the main problem is to differentiate hematoma - hemangioma – hemangiosarcoma. The difficulty lies in the fact that cytological examination is uninformative due to dilution of the sample with blood, and fine needle aspiration biopsy often gives false negative results, since there are extensive areas of hematomas and normal blood vessels inside the tumor. As a result of the research, the authors reduced the volume of tumor masses by 70% due to the use of electrochemotherapy procedure "Bleomecin" and eletroporation with calcium glucanate.</p></abstract><trans-abstract xml:lang="ru"><p>В статье описан клинический случай лечения гемангиосаркомы у собаки породы лабрадор в возрасте 7 лет, местного контроля опухоли с помощью применения внутривенного введения блеомицина и последующей элетропорацией опухоли, а также сочетанное введение кальция глюконата непосредственно в область опухолевого узла. Гемангиосаркома – злокачественная опухоль, достаточно часто встречается у собак в среднем и старшем возрасте. Наиболее предрасположены к данному заболеванию собаки пород лабрадоры, немецкие овчарки и ретриверы. Причины возникновения выявленного онкологического заболевания пока еще не известны, но можно с уверенностью сказать, что основными органами, которые поражаются у животного чаще, являются селезенка, правое предсердие, кожа и подкожная клетчатка, сальник, брыжейка, печень. У 25% собак с опухолью селезенки поражается сердце. Опухоли, затрагивающие только эпителий кожи, условно злокачественные. Реже – легкие, почки, ротовая полость, мышцы, кости, мочевой пузырь, левый желудочек, надпочечники, мозг, диафрагма, брюшина, лимфоузлы, язык и пальцы. Гемангиосаркома – высокоагрессивная опухоль, метастазирует гематогенно или имплантационно. Собаки без лечения живут до 3 месяцев, с лечением – до 6 месяцев, 10% больных переживают год. Наряду с методикой лечения гемангиосаркомы описан и процесс диагностики, т.к. основная проблема – это дифференцировать гематому – гемангиому – гемангиосаркому. Сложность заключается в том, что цитологическое исследование малоинформативно из-за разбавления образца кровью, а тонкоигольная аспирационная биопсия часто дает ложноотрицательные результаты, так как внутри опухоли имеются обширные зоны гематом и нормальных кровеносных сосудов. В результате исследований, благодаря применению процедуры электрохимиотерапии «Блеомецина» и элетропорации глюканатом кальция авторам уменьшить объем опухолевых масс на 70%.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hemangiosarcoma</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>electrochemotherapy</kwd><kwd>bleomycin</kwd><kwd>dog</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гемангиосаркома</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>электрохимиотерапия</kwd><kwd>блеомицин</kwd><kwd>собака</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Baez, J. L., Hendrick, M. J., Shofer, F. S., Goldkamp, C., &amp; Sorenmo, K. U. (2004). Liposarcomas in dogs: 56 cases (1989-2000). Journal of the American Veterinary Medical Association, 224(6), 887-891.</mixed-citation><mixed-citation xml:lang="ru">Baez J., Hendrick M., Shofer F., et al. 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