Studies in Solid Solution Formation between Acetaminophen and Povidone and Mouth-dissolving Strip Formulation
- Autores: Shahiwala A.1
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Afiliações:
- Pharmaceutics Department, Dubai Pharmacy College
- Edição: Volume 30, Nº 15 (2024)
- Páginas: 1200-1208
- Seção: Immunology, Inflammation & Allergy
- URL: https://bulletin.ssaa.ru/1381-6128/article/view/645633
- DOI: https://doi.org/10.2174/0113816128297499240321034304
- ID: 645633
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Resumo
Introduction:This invention reports the solubilization of Acetaminophen (ACM) within the Povidone (PVP K30) in the solid state for the first time.
Methods::First-generation solid dispersions (SDs) were attempted with a different ratio of PVP K:30:ACM. SDs prepared were transparent, suggesting a solid solution (SS) formation, which was a serendipitous discovery. A minimum ratio of 1.25:1 PVP K30: ACM was required to form stable SS, suggesting discontinuous SS. A computational complex prediction tool, fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) confirmed the SS formation.
Results:The oral strip formulation was developed from the PVP K30: ACM SS using Polyvinyl alcohol as a film-former found to be optimum concerning physicochemical properties, offering rapid drug dissolution and taste masking.
Conclusion:The designed strip is suitable for delivering a child's dose (100-150 mg). However, the developed SS can be formulated as tablets, capsules, or oral dissolving tablets to deliver adult doses with improved therapeutic benefits and patient compliance.
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Sobre autores
Aliasgar Shahiwala
Pharmaceutics Department, Dubai Pharmacy College
Autor responsável pela correspondência
Email: info@benthamscience.net
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