ACTIVITY OF ASPARTATE AMINOTRANSFERASE IN THE TISSUES OF THE DUODENUM IN RABBITSIN DIFFERENT PHASES OF POSTNATAL ONTOGENESIS

The purpose of the study is improving different body systems of animals in separate development phases of postnatal ontogenesis. To achieve this goal we studied the patterns of age-related changes of the activity of aspartate aminotransferase in the tissues of the duodenum of rabbits in different phases. Used rabbits breed gray giant at the age 1, 6, 12, 18, 24, 30, 45, 60, 90 and 120 days. The duodenum was divided into three parts: proximal, medial and distal. In every part of the duodenum was isolated two layers: mucous and muscle. In their studies of early postnatal life of rabbits was divided into phases. The studies show that due to changes in the structure and function of the muscular and mucous layers of the mucous membrane of the duodenum, due to changes in the composition and amount of food the activity of the enzyme varies. The activity of AST in the tissues of the mucous and muscle layers of the proximal, medial and distal parts of the duodenum at the age 1 day of rabbits in the colostrum nutrition phase, compared with other age groups, relatively low. In the first six days of life, in colostrum nutrition phase, the enzyme activity increases significantly. To twelve daily age rabbits, in the first dairy feeding phase, the activity of AST also increased significantly. Subsequently, the daily age of eighteen, in the second phase of dairy feeding, the activity of AST decreased significantly in the tissues of both layers ofthe proximal, medial and distal parts of the duodenum. Fromthedailyage of eighteen of rabbits in the tissues mucous layer of the proximal, medial and distal parts and in muscle layer of the distal part of the duodenum, the activity of AST is stabilized. In the muscle layer of the proximal and medial parts of the gut in subsequent phases of feeding rabbits the nature and intensity of age-related changes in activity of AST are slightly different. These distinctive features in the muscle layer of the mentioned parts of the duodenum, possibly associated with peculiarities of generation of their structure. Thus, the most intensive processes of transamination of aminoacids with the participation of aspartate aminotransferase in the examined tissues are seen in rabbits at early stages of postnatal period, toeighteendayold.

rabbits, aspartate aminotransferase, duodenum, intestine, enzyme, phase, power